Australia will field three debutants in the top six in a new-look side to take on Pakistan.
Aaron Finch, Travis Head and Marnus Labuschagne will all receive a Baggy Green, joining Usman Khawaja as well as Shaun and Mitch Marsh in the batting line-up.
The omission is Matt Renshaw, who copped a knock to the head fielding at short leg earlier in the week.
Peter Siddle will also return to the side, easing out Michael Neser for the second seam bowling spot.
He will be joined by fellow Victorian Jon Holland, who will support Nathan Lyon with his spin bowling.
Australia XI for first Test:
Aaron Finch, Usman Khawaja, Shaun Marsh, Mitch Marsh, Travis Head, Marnus Labuschagne, Tim Paine (c), Mitchell Starc, Peter Siddle, Nathan Lyon, Jon Holland